Have you tried Ocrelizumab (Ocrevus)?

@Alexis I tested JC positive on Tysabri and the Ocrevus has been a great medication  for me.  You have to remember, like every patient, every medication may have different results for patients.

Hello. I am currently taking Ocrevus. I have been on this medication for a year. I have no complaints about the medication. I believe it could help a lot of people.

I agree 100%, the only drawback is the time the infusion takes to administer

I've been on  Ocrevus for about two years now and I'm stable with my disease. 

I have  been on  Ocvrevus since  last  May and I am  very happy  with  it.  I  was  only diagnosed  right  before  that  but  my neurologist  said  Ocvrevus  is the best  medication  out there. 

I've been on ocrevus for about 2 years myself haven't seen an improvement in my legs but no flares so I'm happy with that. Neurologist has seen improvements in my left arm. Which is my weak-side but I use that arm to get my Walker into the backseat of my car, I think that lifting has been what's helped my left arm.

I have been on Ocrevus for about a year and a half. I feel the medication is doing good for me. The only problem is with my right leg. When I walk, my right leg is bothersome to bend and walk like I use to.

For me and my left leg is still troublesome I still have foot drop. I'm not flaring so I just managed with a troublesome leg. I use a walker now a tall one all the time. I started off with one cane and then two canes, then  a walker and now I use a tall walker with arm rests.

Hello, I've been on Ocrevus for three years I started when I was first diagnosed with Primary progressive MS, my last treatment was in September, for the first time I lost a lot of hair, this had never happened before, and I hope it doesn't ever happen again. But it has slowed the Progression , I was told with the many Lessions I have that I should be in a wheelchair, it's been three years and still walking. I have two beautiful grandson's and I right the right for them. I am getting depressed having to stay home with this Virus, I sell Real estate and my doctor put me in quarantine other than when it's a necessity. How's everyone coping with this.

@mikeand75 I have found a lot of people on Ocrevus have had increase in walking issues. I have torn my ACL AND MCL due to leg weakness and falls. I'm having to get surgery on my right knee soon. It's the same leg with my gait. I was fine walking wise before taking Ocrevus. I'm a member of the Ocrevus page on Facebook and its a common thing I see. A lot of people have reported it to the manufacturer to add it to the side effect list.