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Patients Ulcerative colitis

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Member Carenity
Posted on

So I was on the Humira injection for 4 years and apparently I developed a Drug-resistant Antibodies last spring and came out of remission over the last year. My doctor just changed me over to the Remicade infusion. My question is, what is the likelihood that I could develop drug-resistant antibodies to the Remicade and how soon? Because I know that these treatments are pretty much the end of the road for people suffering with ulcerative colitis. I am out of remission and have more frequent flares and urgency.

Beginning of the discussion - 3/25/19

Drug Resistant Antibodies
Member Carenity
Posted on

So I can't answer your question but I'm wondering the same thing. I wanted to comment because I'm in the same situation. I've been on Remicade for a little over a year but I've developed antibodies to it so tomorrow I'm seeing the doctor because she wants to start me on a new medication. I've researched the biologics used to treat ulcerative colitis and I was going to ask the doctor about Humira. Did you experience any side effects? Honestly, the possible side effects that these meds can cause scare me. I feel like they may keep the UC under control but they can cause other life threatening issues. At this point, I'm just going to take my chances and see how I do with just taking Delzicol and Canasa at home. 

Drug Resistant Antibodies
Member Carenity
Posted on

The only side effect I really felt like I had from Humira was a decreased immune response. I had quite a few colds and viruses while I was on it as it knocks out your appropriate immune response. But any biologic does that. Other than that, it put me in remission for about three years before I developed the drug-resistant antibodies. Remicade and Humira are pretty much the gold standard for Biologics as far as Crohn's and ulcerative colitis go. A lot of doctors tried to treat with other medications such as Mesalamine and Bentyl, but I have not had luck with those. When I have no other choice but to take those after the Remicade stops working I do not want to know what I'm going to do. Unfortunately I am in the middle of a pretty significant flare myself and I'm hoping the Remicade will help me.Good luck!

Drug Resistant Antibodies
Member Carenity
Posted on

From what I have learned, with all medications there is a piossibility that a person can develop defense against it and therefore it stops working as well. This is true with UC treatments, diabete treatments, depression, etc. It is more prone to happen when someone does not finish their full dose or goes off and then goes back on. It is always a possibility - that is why it is so important for one not to stop their medicatin abruptly by themselves. I have heard the most danger is with antibiotics.