«
»

Top

Could 'one puff' of cannabis ease depression?

Published Apr 26, 2018

Could 'one puff' of cannabis ease depression?

A new study sheds light on how different quantities of tetrahydrocannabinol and cannabidiol — the psychoactive compounds in cannabis — affect levels of stress, anxiety, and depression.
 
marijuanasmoke

Researchers reveal how different concentrations of cannabinoids might impact anxiety, stress, and depression.
Researchers from Washington State University (WSU) found that adults reported a reduction in depressive symptoms with just a single puff of medical marijuana that was high in cannabidiol (CBD) and low in tetrahydrocannabinol (THC).

The team also found that at least 10 puffs of marijuana high in both CBD and THC led to significant reductions in self-reported stress, while two puffs of cannabis with any level of CBD or THC led to a reduction in anxiety.

However, the study also found that long-term use of medicinal marijuana may actually exacerbate symptoms of depression.

Lead study author Carrie Cuttler, of the Department of Psychology at WSU, and colleagues recently reported their results in the Journal of Affective Disorders.

Alleviation of anxiety, stress, and depression are the among the most common reasons why people use cannabis, but does the drug really work? To date, the few studies that have attempted to answer this question have produced mixed results.

"Existing research on the effects of cannabis on depression, anxiety, and stress are very rare," says Cuttler, "and have almost exclusively been done with orally administered THC pills in a laboratory."


Studying data from a cannabis app
For this latest research, Cuttler and colleagues set out to investigate how different concentrations of THC and CBD in cannabis affect users' symptoms of anxiety, stress, and depression when inhaled.

THC and CBD are the two most common cannabinoids — which are chemical compounds that act on cannabinoid receptors in the brain — found in cannabis.

"What is unique about our study," Cuttler explains, "is that we looked at actual inhaled cannabis by medical marijuana patients who were using it in the comfort of their own homes as opposed to a laboratory."

To reach their findings, Cuttler and team analyzed data from Strainprint, a Canadian app used to track medical cannabis use and the symptom severity of almost 280 medical conditions.

For this study, Cuttler and colleagues assessed around 12,000 entries of adults who used the app to track symptoms of anxiety, stress, and depression.

Users of the app reported their gender, method of cannabis use, quantity of cannabis use (such as the number of puffs taken when smoking the drug), and the percentage of THC and CBD in their cannabis.

Around 20 minutes after drug administration, users are required to report symptom severity on a scale ranging from 1–10.

Chronic use may worsen depression
Overall, users reported that their symptoms of depression halved as a result of medical cannabis use, while symptoms of anxiety and stress were reduced by 58 percent.

On looking at how the concentrations of THC and CBD affected symptom severity, the team found that just one puff of high-CBD, low-THC cannabis was enough to lower depressive symptoms, while two puffs of any form of cannabis were tied to a reduction in anxiety.

For symptoms of stress, at least 10 puffs of high-CBD, high-THC cannabis produced the greatest benefit.

According to the researchers, these findings contradict popular notion that THC is the most beneficial cannabinoid for mental health. "A lot of consumers seem to be under the false assumption that more THC is always better," says Cuttler.

"Our study shows that CBD is also a very important ingredient in cannabis and may augment some of the positive effects of THC."

What Are Your Thoughts?

Medical News Today

2 comments

gottgetbtr
on 5/1/18

I tried CBD oil, but it did not do much for my clavicle/collar bone pain or my nerve pain into my arm.

You will also like

Are you interested in CBD oil to help manage your chronic condition?

Generalized anxiety disorder
Schizotypal personality disorder
Social anxiety disorder

Are you interested in CBD oil to help manage your chronic condition?

Read the article
Staying positive and living with depression since age 8

Post traumatic stress disorder
Social anxiety disorder

Staying positive and living with depression since age 8

See the testimonial
 One In Three Americans Take Meds With Depressive Side Effects: Study

Agoraphobia
Alexithymia
Autism Spectrum Disorder
Behavioural disorders / Mental illness
Beta-thalassemia
Bipolar disorder
Borderline personality disorder
Cardiac conduction defect syndrome
Childhood disintegrative disorder
Claustrophobia
Coffin-Lowry syndrome
Cyclothymia
Delirious flushes
Depersonalization disorder
Dissociative identity disorder
Dysmorphic disorder
Dysthymia
Frontotemporal dementia
Frontotemporal dementia with tau inclusions
Generalized anxiety disorder
Gilles de la Tourette syndrome
Hyperactivity
Hypomania
Identity Crisis
Impostor syndrome
Learning disabilities (Dys)
Lubie
Melancholy
Mitral valve disorder
Multiple Complex Developmental Disorder
Neurosis
Obsessive compulsive disorder
Panic attack
Paranoia
Pathological demand avoidance syndrome
Phobias
Post traumatic stress disorder
Psychogenic non-epileptic seizures
Psychosis
Psychotic disorder
Schizotypal personality disorder
Seasonal affective disorder
Secondary Trauma
Social anxiety disorder
Stress
Tics
Trichotillomania
xyz_Chronic anxiety

 One In Three Americans Take Meds With Depressive Side Effects: Study

Read the article
See the testimonial

Fact sheet